Coronary arteries of 33 domestic pig were treated with the DIOR® drug-eluting balloon in a time-dependent matter. Arteries were dissected and sent to a blinded laboratory for paclitaxel determination. Histomorphometry and histopathology were performed two weeks after dilatation.
Lumen Area and Neointima area (mm²) at FU
Vessels treated with DIOR® DEB show significantly higher lumen area and significantly lower neointima area two weeks after dilatation compared to uncoated balloon treatment.
Area Stenosis (%) at FU
Vessels treated with DIOR® DEB show significantly lower area of stenosis after two weeks follow-up compared to uncoated balloon treatment.
Tissue paclitaxel concentration (μmol/l)
Inflation of 45s with DIOR® DEB leads to long presence and high concentration of paclitaxel in the arterial wall – crucial for inhibition of neointimal proliferation and restenosis.