Cytotoxicity Analysis DEB

Investigation of Cytotoxicity


With the help of in-vitro experiments, shellac was found not to impair viability of Endothelial cells(EC) and smooth muscle cells (SMC)Both cell types are important in arteriosclerotic progression and come into direct contact with intravascular devices during angioplasty.

On further investigating, it was also found that to not induce proliferation of SMC nor change the inflammatory status of EC thus making shellac suitable and safe for coating drug eluting balloons.

Cytotoxicity Shellac


Peters K et al. (2012) In Vitro Evaluation of Cytocompatibility of Shellac as Coating for Intravascular Devices. Trends Biomater Artif Organ 26(2): 110-11.